PIA

An R package PIA

@ Overview

The PIA is an R package enabling genetics-led and network-driven drug target prioritisation for asthma.

@ Installation

1. Install R

Please install R (version 4.2.1 or above); see https://cran.r-project.org

If installed on Ubuntu (assuming you have a ROOT (sudo) privilege), please do so below

sudo su
# here enter your password

wget http://www.stats.bris.ac.uk/R/src/base/R-4/R-4.2.1.tar.gz
tar xvfz R-4.2.1.tar.gz
cd ~/R-4.2.1
./configure
make
make check
make install
R # start R

2. Install R packages

R # start R

# if the package 'BiocManager' not installed, please do so
if(!("BiocManager" %in% rownames(installed.packages()))) install.packages("BiocManager")

# first, install basic packages: remotes, tidyverse
BiocManager::install(c('remotes','tidyverse'), dependencies=T)

# then, install the package 'PIA' (now hosted at github)
BiocManager::install("hfang-bristol/PIA", dependencies=T, force=T)

# check the package 'PIA' successfully installed
library(help=PIA)

@ Showcase

A showcase describing step-by-step instructions on how to identify shared and distinct drug targets for adult- and childhood-onset asthma is made reproducible here.

@ Contact

Please drop email for bug reports or other enquiries.